Motif ID: STAT5{A,B}.p2

Z-value: 0.958


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B



Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_203503214 2.330 TMCC2
transmembrane and coiled-coil domain family 2
chr19_+_49361054 1.976 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr19_+_49309350 1.771 NM_013362
ZNF225
zinc finger protein 225
chr3_+_66094324 1.664 NM_173471
SLC25A26
solute carrier family 25, member 26
chr1_-_206125877 1.594


chr19_-_53941835 1.585 NM_182575
IZUMO1
izumo sperm-egg fusion 1
chr13_+_51334117 1.483 NM_031290
CCDC70
coiled-coil domain containing 70
chr19_+_49290319 1.383 NM_013398
ZNF224
zinc finger protein 224
chr4_-_77176163 1.337 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr14_-_19951417 1.298 NM_007110
TEP1
telomerase-associated protein 1
chr3_+_171422940 1.287 PRKCI
protein kinase C, iota
chr11_+_36572615 1.286 NM_138787
C11orf74
chromosome 11 open reading frame 74
chr19_+_49180171 1.204 NM_003445
NM_198089
ZNF155

zinc finger protein 155

chr19_+_49408523 1.200 NM_182490
ZNF227
zinc finger protein 227
chr2_+_95195260 1.187 ZNF2
zinc finger protein 2
chr3_+_171422917 1.155 PRKCI
protein kinase C, iota
chr19_-_49500966 1.129 NM_004234
ZNF235
zinc finger protein 235
chr19_+_42400908 1.103 ZNF383
zinc finger protein 383
chr19_+_49248003 1.076 NM_013361
ZNF223
zinc finger protein 223
chr8_-_66708954 1.044 ARMC1
armadillo repeat containing 1
chr7_+_89870707 1.033 CLDN12
claudin 12
chr3_+_171422908 1.028 NM_002740
PRKCI
protein kinase C, iota
chr8_-_66708948 1.025 ARMC1
armadillo repeat containing 1
chr19_-_49552638 1.010 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr15_+_39853923 0.992 NM_001128608
NM_014994
MAPKBP1

mitogen-activated protein kinase binding protein 1

chr19_+_62972861 0.980 ZNF586
zinc finger protein 586
chr7_-_93471463 0.949 NM_005868
BET1
blocked early in transport 1 homolog (S. cerevisiae)
chr7_-_112545840 0.943 LOC401397
hypothetical LOC401397
chr12_+_100795213 0.941 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr8_-_66708967 0.926 NM_018120
ARMC1
armadillo repeat containing 1
chr17_+_29606408 0.921 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr1_+_38250995 0.918 UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr15_+_39853982 0.900 MAPKBP1
mitogen-activated protein kinase binding protein 1
chr11_-_82674546 0.887 CCDC90B
coiled-coil domain containing 90B
chr7_+_89870647 0.872 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr7_-_132417374 0.846 CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr1_+_54291847 0.824 NM_153035
TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr9_+_103200939 0.804 NM_003452
NM_197977
ZNF189

zinc finger protein 189

chr15_+_64661560 0.799


chr6_+_139136349 0.795 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr1_-_33275051 0.764 AK2
adenylate kinase 2
chr1_-_33275015 0.762 AK2
adenylate kinase 2
chr1_-_33275039 0.755 AK2
adenylate kinase 2
chr19_+_62950001 0.752 ZNF776
zinc finger protein 776
chr1_+_40769877 0.744 ZNF684
zinc finger protein 684
chr18_-_45241014 0.723 NM_017653
DYM
dymeclin
chr19_-_49131250 0.713 NM_003425
ZNF45
zinc finger protein 45
chr17_-_35464137 0.712 MED24
mediator complex subunit 24
chr6_+_84626146 0.704 CYB5R4
cytochrome b5 reductase 4
chr4_+_2853434 0.699 ADD1
adducin 1 (alpha)
chr1_+_38250953 0.698 NM_016037
UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr2_-_85435074 0.693 NM_017750
RETSAT
retinol saturase (all-trans-retinol 13,14-reductase)
chr2_+_173394560 0.684 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr16_-_219111 0.680


chr9_-_103200697 0.671 NM_019051
MRPL50
mitochondrial ribosomal protein L50
chr19_+_9112052 0.670 NM_001190791
NM_020933
ZNF317

zinc finger protein 317

chr1_-_33275071 0.649 NM_013411
AK2
adenylate kinase 2
chr7_-_112545847 0.645 LOC401397
hypothetical LOC401397
chr17_+_36636404 0.643 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr19_-_49309102 0.643 LOC100379224
hypothetical LOC100379224
chr9_-_133944877 0.639 MED27
mediator complex subunit 27
chr6_+_84626113 0.625 CYB5R4
cytochrome b5 reductase 4
chr11_-_133628348 0.604 NM_001037304
NM_001037305
NM_014174
NM_199297
NM_199298
THYN1




thymocyte nuclear protein 1




chr1_-_33275057 0.597 NM_001625
AK2
adenylate kinase 2
chr7_-_132417237 0.595 NM_017812
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr10_-_98315090 0.586 TM9SF3
transmembrane 9 superfamily member 3
chr19_-_42777486 0.580 NM_016536
ZNF571
zinc finger protein 571
chr19_+_49337568 0.578 ZNF234
zinc finger protein 234
chr14_-_76958984 0.575 NM_138791
NM_001113475
C14orf148

chromosome 14 open reading frame 148

chr19_-_61596681 0.569 NM_144690
ZNF582
zinc finger protein 582
chr16_+_52295545 0.568 FTO
fat mass and obesity associated
chr19_+_39860398 0.568 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr19_-_41672176 0.562 NM_032838
NM_001145343
NM_001145344
NM_001145345
ZNF566



zinc finger protein 566



chr19_+_45168872 0.556 NM_006503
NM_153001
PSMC4

proteasome (prosome, macropain) 26S subunit, ATPase, 4

chr19_+_17239264 0.549 BABAM1
BRISC and BRCA1 A complex member 1
chr17_-_44847215 0.547 NM_002634
PHB
prohibitin
chr19_+_55844446 0.545 NM_001195076
LOC342918
hypothetical protein LOC342918
chr3_+_140545528 0.543 NM_020191
MRPS22
mitochondrial ribosomal protein S22
chr19_+_62638474 0.543 NM_001023561
ZNF749
zinc finger protein 749
chr5_+_14493905 0.541 TRIO
triple functional domain (PTPRF interacting)
chr17_-_23721468 0.539 VTN
vitronectin
chr6_+_84626083 0.539 NM_016230
CYB5R4
cytochrome b5 reductase 4
chr3_-_158695832 0.535 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr11_+_133628616 0.515 NM_014384
ACAD8
acyl-CoA dehydrogenase family, member 8
chr17_-_23721485 0.515 NM_000638
VTN
vitronectin
chr10_+_93548048 0.515 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr1_+_151897768 0.508 NM_012437
SNAPIN
SNAP-associated protein
chr3_+_199161446 0.503 NM_000996
RPL35A
ribosomal protein L35a
chr19_+_49198916 0.502 NM_006300
ZNF230
zinc finger protein 230
chr18_+_41938295 0.495 NM_138443
HAUS1
HAUS augmin-like complex, subunit 1
chr2_+_95194903 0.492 NM_001017396
NM_021088
ZNF2

zinc finger protein 2

chr7_-_133652289 0.484 NM_032826
SLC35B4
solute carrier family 35, member B4
chr12_+_12857516 0.478 NM_016355
NM_201224
DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr5_-_102926349 0.473 NM_031438
NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr17_+_5264195 0.471 RPAIN
RPA interacting protein
chr17_-_18526296 0.467 NM_001145045
ZNF286B
zinc finger protein 286B
chr19_-_41711009 0.466 NM_001012756
NM_001166036
NM_001166037
NM_001166038
ZNF260



zinc finger protein 260



chr17_+_7457988 0.463 SHBG
sex hormone-binding globulin
chr19_+_62949972 0.460 NM_173632
ZNF776
zinc finger protein 776
chr6_-_30766621 0.460 NM_007243
NRM
nurim (nuclear envelope membrane protein)
chr19_+_49337548 0.459 NM_001144824
NM_006630
ZNF234

zinc finger protein 234

chr19_-_49097774 0.453 LOC100505715
hypothetical LOC100505715
chr2_+_171999042 0.452 DCAF17
DDB1 and CUL4 associated factor 17
chr11_+_5466490 0.451 NM_001005163
OR52D1
olfactory receptor, family 52, subfamily D, member 1
chr17_-_44847214 0.449 PHB
prohibitin
chr6_-_27548438 0.440 NM_007149
ZNF184
zinc finger protein 184
chr13_-_24395054 0.439 NM_018451
CENPJ
centromere protein J
chr6_+_20642665 0.437 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr18_+_54958095 0.435 NM_033280
SEC11C
SEC11 homolog C (S. cerevisiae)
chr17_+_15543771 0.429 ZNF286A
zinc finger protein 286A
chr1_-_120737466 0.427 NM_001004340
NM_001017986
FCGR1A
FCGR1B

Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)

chr21_-_35174742 0.423 RUNX1
runt-related transcription factor 1
chr11_+_2877486 0.421 NM_183233
SLC22A18
solute carrier family 22, member 18
chr3_+_185537969 0.414 NM_144635
FAM131A
family with sequence similarity 131, member A
chr19_+_50601708 0.413 CD3EAP
CD3e molecule, epsilon associated protein
chr1_-_120737416 0.411 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr9_-_133945064 0.401 NM_004269
CRSP8P
MED27
mediator complex subunit 27 pseudogene
mediator complex subunit 27
chr10_+_93548162 0.400 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr8_-_109330116 0.399 NM_001568
EIF3E
eukaryotic translation initiation factor 3, subunit E
chr17_+_36515166 0.396 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr17_-_23721430 0.394 VTN
vitronectin
chr19_+_49268106 0.384 NM_001037813
ZNF284
zinc finger protein 284
chr5_-_95184121 0.383 GLRX
glutaredoxin (thioltransferase)
chr7_-_133652042 0.380 SLC35B4
solute carrier family 35, member B4
chr19_+_40900965 0.377 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr1_+_40769819 0.375 NM_152373
ZNF684
zinc finger protein 684
chr3_+_132228383 0.371 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr2_+_43854681 0.366 NM_001193464
NM_015522
NM_016008
DYNC2LI1


dynein, cytoplasmic 2, light intermediate chain 1


chr19_+_63508569 0.363 LOC100506584
hypothetical protein LOC100506584
chr11_-_123918759 0.361 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr11_+_71317736 0.361 RNF121
ring finger protein 121
chr15_+_72540655 0.360 LOC440288
similar to FLJ16518 protein
chr1_+_161305188 0.358 NM_005613
RGS4
regulator of G-protein signaling 4
chr8_-_102034730 0.356 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr4_+_130236731 0.356 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr1_+_174698929 0.345 NM_020318
NM_021936
PAPPA2

pappalysin 2

chr16_+_10945815 0.344 NM_015226
CLEC16A
C-type lectin domain family 16, member A
chr12_+_4700012 0.344 NM_017417
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr4_-_89299034 0.342 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr2_+_63669596 0.341 NM_005917
MDH1
malate dehydrogenase 1, NAD (soluble)
chr15_+_73102984 0.341 PPCDC
phosphopantothenoylcysteine decarboxylase
chr5_-_137542198 0.340 NM_001164326
NM_006696
NM_139199
BRD8


bromodomain containing 8


chr14_+_67356248 0.339 NM_002877
NM_133509
NM_133510
RAD51L1


RAD51-like 1 (S. cerevisiae)


chr3_+_129682434 0.338


chr10_+_93548119 0.335 NM_025235
TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr10_+_86174665 0.332 FAM190B
family with sequence similarity 190, member B
chr19_+_49023283 0.331 NM_181845
ZNF283
zinc finger protein 283
chr5_-_95184221 0.329 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr22_+_37407921 0.326 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr18_-_41938196 0.325 NM_001001937
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr15_+_73102979 0.324 NM_021823
PPCDC
phosphopantothenoylcysteine decarboxylase
chr22_+_37407906 0.321 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr9_-_129226312 0.319


chr19_+_39916964 0.313 ZNF181
zinc finger protein 181
chr17_-_16038607 0.311 NM_001190438
NM_001190440
NCOR1

nuclear receptor corepressor 1

chr5_+_32621361 0.302 NM_006713
SUB1
SUB1 homolog (S. cerevisiae)
chr3_+_123882355 0.302 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr3_+_197951121 0.299 NM_002577
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr17_-_23721351 0.298 VTN
vitronectin
chr19_-_49644470 0.295 NM_014518
ZNF229
zinc finger protein 229
chr1_+_161305558 0.288 NM_001113381
RGS4
regulator of G-protein signaling 4
chr17_-_23721420 0.285 VTN
vitronectin
chr11_+_113672378 0.285 NNMT
nicotinamide N-methyltransferase
chr19_+_17391841 0.285 FAM125A
family with sequence similarity 125, member A
chr19_+_44082410 0.280 NM_001001716
NM_002503
NFKBIB

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

chr1_+_109827975 0.278 NM_153340
ATXN7L2
ataxin 7-like 2
chr1_-_3763620 0.277 NM_014704
KIAA0562
KIAA0562
chr19_+_63508526 0.276 LOC100506584
hypothetical protein LOC100506584
chr5_+_178383381 0.275 NM_001136116
ZNF879
zinc finger protein 879
chr8_-_102034777 0.274 NM_003406
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr6_+_100075572 0.268 NM_001195131
LOC100130890
hypothetical protein LOC100130890
chr7_+_92699588 0.267 NM_017667
NM_024553
CCDC132

coiled-coil domain containing 132

chr13_-_24394913 0.267 CENPJ
centromere protein J
chr19_+_17239148 0.266 NM_001033549
NM_014173
BABAM1

BRISC and BRCA1 A complex member 1

chr1_-_54291634 0.266 NM_004872
TMEM59
transmembrane protein 59
chr10_-_38305458 0.265 NM_145011
ZNF25
zinc finger protein 25
chr8_-_109330101 0.264 EIF3E
eukaryotic translation initiation factor 3, subunit E
chr2_-_63669022 0.262 WDPCP
WD repeat containing planar cell polarity effector
chr15_-_27901628 0.261 TJP1
tight junction protein 1 (zona occludens 1)
chr19_+_42033564 0.261 ZNF345
zinc finger protein 345
chr9_-_112139908 0.260 NM_001003936
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr19_-_39859997 0.251


chr8_+_18293034 0.251 NM_000015
NAT2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr6_-_83960351 0.249 PGM3
phosphoglucomutase 3
chr17_+_36665161 0.247 NM_030975
KRTAP9-9
keratin associated protein 9-9
chr19_+_13090101 0.244 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr19_+_3713650 0.236 NM_172251
MRPL54
mitochondrial ribosomal protein L54
chr8_+_124154079 0.234 NM_001145088
NM_145647
WDR67

WD repeat domain 67

chr3_+_197951203 0.234 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr8_-_99375739 0.233 NM_024759
NIPAL2
NIPA-like domain containing 2
chr6_+_135860631 0.232 NCRNA00271
non-protein coding RNA 271
chr2_+_27740254 0.227 SLC4A1AP
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr2_-_171998681 0.226 METTL8
methyltransferase like 8
chr22_+_37407925 0.222 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr17_+_15543615 0.221 NM_001130842
NM_020652
ZNF286A

zinc finger protein 286A

chr19_+_17391856 0.221 NM_138401
FAM125A
family with sequence similarity 125, member A
chr17_+_30938470 0.218 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr1_+_153374900 0.218 NM_001122837
NM_001122839
NM_018845
SLC50A1


solute carrier family 50 (sugar transporter), member 1


chr1_+_177317827 0.216 TOR3A
torsin family 3, member A
chr19_+_49221333 0.214 NM_001129996
NM_013360
ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.65 1.41e-04 GO:0060255 regulation of macromolecule metabolic process
1.75 7.37e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.73 1.01e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.67 1.93e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.76 2.31e-03 GO:0006355 regulation of transcription, DNA-dependent
1.55 3.15e-03 GO:0031323 regulation of cellular metabolic process
1.66 3.44e-03 GO:0009889 regulation of biosynthetic process
1.65 4.30e-03 GO:0031326 regulation of cellular biosynthetic process
1.50 4.45e-03 GO:0019222 regulation of metabolic process
1.66 6.10e-03 GO:0010468 regulation of gene expression
1.70 8.49e-03 GO:0051252 regulation of RNA metabolic process
1.52 1.01e-02 GO:0080090 regulation of primary metabolic process
1.61 1.52e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.49 1.46e-06 GO:0005634 nucleus
1.30 1.13e-05 GO:0043231 intracellular membrane-bounded organelle
1.30 1.26e-05 GO:0043227 membrane-bounded organelle
1.26 1.93e-05 GO:0043229 intracellular organelle
1.26 2.33e-05 GO:0043226 organelle
1.18 1.31e-03 GO:0044424 intracellular part
1.16 6.83e-03 GO:0005622 intracellular

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.01 4.09e-07 GO:0008270 zinc ion binding
1.84 1.09e-05 GO:0046914 transition metal ion binding
1.79 4.65e-05 GO:0003677 DNA binding
1.49 8.42e-03 GO:0003676 nucleic acid binding
9.08 4.44e-02 GO:0015035 protein disulfide oxidoreductase activity